After an App-V Server upgrade from Application Virtualization Server 184.108.40.20680 to 220.127.116.1140 we encountered the following error:
The Application Virtualization Client could not launch ApplicationName.
The package requested could not be found in the system data store or the files associated with this package could not be found on the server. Report the following error code to your System Administrator.
Error code: XXXXXX-XXXXXX0A-20000194
After some deep digging we (Ali) found out that the App-V Management Server Installer set the CONTENT_DIR back to the default value! As we don’t use the default content dir C:\Program Files\Microsoft System Center App Virt Management Server\App Virt Management Server\content we found our problem.
Solve this by manually change the registry key SOFTGRID_CONTENT_DIR (in HKLM\SOFTWARE\Microsoft\SoftGrid\4.5\Server) to your current Content location (for example \\servername\contentdir).